Long-Term Changes in Cytokine and Ghrelin Levels Following Laparoscopic Sleeve Gastrectomy in Obese Individuals

Spyridon Spanakos1*, Dimitris Spanakos2 , Evangelos Menenakos3 , Konstantinos Toutouzas4 and Nikolaos Koliakos5

1Department of Plastic Surgery, Microsurgery and Burns Unit, General Hospital of Athens, Greece 2Department of Chemical Engineering, University of Nottingham, UK 3Department of Propaedeutic Surgical, Medical School, National and Kapodistrian University of Athens, Greece 4Department of Surgical, Medical School, National and Kapodistrian University of Athens, Hospital of Athens Hippokrateio, Greece 5Department of Surgery, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Greece

^*Correspondance to: Spyridon Spanakos 

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Abstract:

Obesity is a complex disease considered as a global epidemic which has been associated with elevated levels of inflammatory cytokines and Ghrelin. Of all the bariatric procedures, laparoscopic sleeve gastrectomy is the most widely used procedure across the globe. This study sought to assess the efficiency of laparoscopic sleeve gastrectomy surgery by measuring long-term changes in inflammatory cytokines and ghrelin levels, in visceral and subcutaneous adipose tissue, at protein and gene expression level. The results showed that protein and gene expressions of inflammatory cytokines in visceral and subcutaneous adipose tissues fall significantly 5 years postoperatively (p0.05). To the best of our knowledge, this is the first study to demonstrate the efficiency of the laparoscopic sleeve gastrectomy surgery by investigating the concentration of inflammatory cytokines and ghrelin, 5 years after surgery.

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Cite the Article:

Spanakos S, Spanakos D, Menenakos E, Toutouzas K, Koliakos N. LongTerm Changes in Cytokine and Ghrelin Levels Following Laparoscopic Sleeve Gastrectomy in Obese Individuals. World J Surg Surgical Res. 2021;4:1349..