Application of Platelet-Rich Fibrin (PRF) in Oral and Maxillofacial Autologous Fat Transplantation

Hao Jia1 , Junrui Zhang1 , Liang Kong1 , Bin Lu1 , Qiang Niu1 , Dan Jin1 , Zhiye Li1 , Xin Zhao2 and Yunpeng Li1 *

1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, China 2Tenth Outpatient Department, 986 Hospital, The Fourth Military Medical University, China

^*Correspondance to: Yunpeng Li 

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Abstract:

Due to its various advantages, including minimal invasiveness, high safety and sufficient availability, autologous fat transplantation has been widely used in the repair of soft tissue defects in the oral and maxillofacial regions; however, its high postoperative fat absorption rate remains a major problem for clinicians. In recent years, it has been found that the high levels of growth factors and dense threedimensional network structure in Platelet-Rich Fibrin (PRF) provide a suitable microenvironment for the growth of fat in transplantation areas, which can promote the adhesion and proliferation of adipose-derived stem cells. PRF is an ideal material to solve the problem of a high fat absorption rate. This article reviews the efforts of clinicians to reduce the absorption rate of fat transplantation, analyzes the effect of PRF on adipose stem cells, summarizes the clinical application of PRF in oral and maxillofacial fat transplantation, and preliminarily summarizes and discusses some problems existing in PRF in oral and maxillofacial fat transplantation. The hope is that PRF will be more widely used in oral and maxillofacial fat transplantation.

Keywords:

Autologous fat transplantation; Platelet-rich fibrin; Oral and maxillofacial

Cite the Article:

Jia H, Zhang J, Kong L, Lu B, Niu Q, Jin D, et al. Application of Platelet-Rich Fibrin (PRF) in Oral and Maxillofacial Autologous Fat Transplantation. World J Surg Surgical Res. 2021; 4: 1352..