The Effect of Simvastatin on Complications Regarding Intraperitoneal Mesh Placement in Potential Septic Environment: Experimental Study in the Rat

Kyziridis D, Mantzoros I, Parpoudi S, Makrantonakis A, Zapsalis K, Gemousakakis G, Bourtzinakou AA, Gkiouliava A, Chatzakis C and Aggelopoulos S

4 Surgical Clinic, School of Medicine, Aristotle University of Thessaloniki, Greece Department of Anesthesiology and Intensive Care, School of Medicine, Aristotle University of Thessaloniki, Greece

^*Correspondance to: Antonia Aikaterini Bourtzinakou 

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Abstract:

Background: Hernia repair with the placement of an intraperitoneal mesh, especially in a septic or potentially septic environment, represents a relatively dangerous situation for postoperative complications. The present experimental study aimed to investigate the effect of simvastatin on the complications of a hernia repair with an intraperitoneal mesh in a potentially septic environment. Materials and Methods: Three groups of 20 Wistar rats were categorized into groups A, B, and C. All rats underwent laparotomy and ciprofloxacin was administered. In groups B and C an enterectomy was performed, while in group C simvastatin was also administered intraperitoneally at a dose of 0.57 mg/kg. After the animals were sacrificed on day 21st, adhesion formation was recorded while a part of the mesh was sent for cultivation. The degree of neovascularization, inflammatory reaction, and fibrosis were also histologically evaluated. Blood samples were taken on the 7th, 14th, and 21st postoperative days to assess the following inflammatory markers: TNFα, IL-1α, and IL-6. Results: In group C, the presence of significantly fewer adhesions as well as better histological results were reported compared to group B (p<0.001). In addition, similar results were found between group C and the control group. IL-1a, IL-6 and TNF-a were found significantly lower in the simvastatin group (p<0.001). Conclusion: Intraperitoneal administration of simvastatin provided results almost identical to mesh placement in a clean environment. Being an easily accessible drug, we believe that it could become a new agent that will help us minimize the postoperative complications after intraperitoneal mesh placement.

Keywords:

Simvastatin; Adhesion; Inflammation; Surgical mesh; Surgical Site; Infection

Cite the Article:

Kyziridis D, Mantzoros I, Parpoudi S, Makrantonakis A, Zapsalis K, Gemousakakis G, et al. The Effect of Simvastatin on Complications Regarding Intraperitoneal Mesh Placement in Potential Septic Environment: Experimental Study in the Rat. World J Surg Surgical Res. 2024; 7: 1549..